Package: POINT 1.3

POINT: Protein Structure Guided Local Test

Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>.

Authors:Rachel Marceau West, Shannon T. Holloway

POINT_1.3.tar.gz
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POINT.pdf |POINT.html✨
POINT/json (API)
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1 exports 3.14 score 7 dependencies 19 mentions 3 scripts 269 downloads

Last updated 12 months agofrom:1f5de2f039. Checks:OK: 7. Indexed: yes.

Exports:point

Dependencies:CompQuadFormlatticeMatrixrARPACKRcppRcppEigenRSpectra